CLASSIC WORKAHOLIC OR ENGAGED WORKAHOLIC ?
Elizabeth Valenzuela, a managing partner at a law firm in Sherman Oaks, has been an attorney for 26 years but sounds like a fresh law school grad when she talks about her work. “There is an excitement about what is around the corner,” says Valenzuela, 51, and to find out what lurks there, she regula …
Tue, 14 Feb 2012 02:13:00 CST
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mas, pasti mas mw UKDI ya?? RT @davidakbars: Happy HHD??..Couple :Happy Heart day,,Single:Hypertension Heart Disease
mas, pasti mas mw UKDI ya?? RT @davidakbars: Happy HHD??..Couple :Happy Heart day,,Single:Hypertension Heart Disease
Nia_Agustiana@twitter.com (Nia Agustiana)
Tue, 14 Feb 2012 09:33:36 +0000
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A Phox2- and Hand2-Dependent Hand1 cis-Regulatory Element Reveals a Unique Gene Dosage Requirement for Hand2 during Sympathetic Neurogenesis.
J Neurosci. 2012 Feb 8; 32(6): 2110-20
Vincentz JW, Vandusen NJ, Fleming AB, Rubart M, Firulli BA, Howard MJ, Firulli AB
Neural crest cell specification and differentiation to a sympathetic neuronal fate serves as an important model for neurogenesis and depends upon the function of both bHLH transcription factors, notably Hand2, and homeodomain transcription factors, including Phox2b. Here, we define a 1007 bp cis-regulatory element 5′ of the Hand1 gene sufficient to drive reporter expression within the sympathetic chain of transgenic mice. Comparative genomic analyses uncovered evolutionarily conserved consensus-binding sites within this element, which chromatin immunoprecipitation and electrophoretic mobility shift assays confirm are bound by Hand2 and Phox2b. Mutational analyses revealed that the conserved Phox2 and E-box binding sites are necessary for proper cis-regulatory element activity, and expression analyses on both Hand2 conditionally null and hypomorphic backgrounds demonstrate that Hand2 is required for reporter activation in a gene dosage-dependent manner. We demonstrate that Hand2 and Hand1 differentially bind the E-boxes in this cis-regulatory element, establishing molecular differences between these two factors. Finally, we demonstrate that Hand1 is dispensable for normal tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) expression in sympathetic neurons, even when Hand2 gene dosage is concurrently reduced by half. Together, these data define a tissue-specific Hand1 cis-regulatory element controlled by two factors essential for the development of the sympathetic nervous system and provide in vivo regulatory evidence to support previous findings that Hand2, rather than Hand1, is predominantly responsible for regulating TH, DBH, and Hand1 expression in developing sympathetic neurons.
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Heart Disease Continues as Leading Killer of Women - Technorati
Technorati
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Heart Disease Continues as Leading Killer of Women
Technorati
The purpose of this campaign is to heighten our awareness of heart disease in the female population. We all have heard the numbers before, but repeated messaging has made the threat somewhat mundane. Heart disease awareness initiatives don't have the …
For Women, Identifying Symptoms Is Key In Treating Heart DiseaseNY1
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Daily News - Galveston County -KTVO -Long Beach Business Journal - Long Beach News
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Tue, 14 Feb 2012 05:15:22 GMT
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CIENCIASMEDICASNEWS: Heart Disease May Be Risk Factor for …
If this link is confirmed in future research, it means that lifestyle changes that reduce heart disease risk — such as weight loss, exercise and a healthy diet — may also protect men against prostate cancer, the Duke Cancer …
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